Abstract
Background: Multiple sclerosis is a chronic heterogeneous demyelinating axonal and inflammatory disease involving the central nervous system [CNS] white matter with a possibility of gray matter involvement in which the insulating covers of nerve cells in the brain and spinal cord are damaged. This damage disrupts the ability of parts of the nervous system to communicate, resulting in a wide range of signs and symptoms. Cerebral venous insufficiency theory was raised as a possible etiology for the disease at 2008 by zamboni an italian cardiothoracic surgeon. This theory was defeated by multiple sclerosis [MS] researchers and scientists who thought that the disease is an autoimmune rather than vascular.
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