Magnetic resonance tractography based on the constrained spherical deconvolution in patients with gliomas of the optic pathway

A A Baev,E I Shults,A M Shkatova,D I Pitskhelauri,A E Bykanov,T A Konakova,N E Zakharova,E L Pogosbekian,S A Maryashev,I N Pronin,A I Batalov

doi:10.18786/2072-0505-2021-49-009

A A Baev, E I Shults + Show 9 more

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https://doi.org/10.18786/2072-0505-2021-49-009

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Abstract

Background: The use of magnetic resonance (MR) tractography in neurosurgery is becoming an increasingly common practice for noninvasive imaging of white matter pathways. The most common method of tract reconstruction is the deterministic algorithm of diffusion tensor magnetic resonance imaging (MRI). However, this method of reconstructing pathways has a number of significant limitations. The most important of them are the lack of the possibility of visualizing the intersecting fibers, the complexity of building tracts in the area of perifocal edema and in the immediate vicinity of the tumor borders. The method of MR tractography, based on obtaining a diffusion image with a high angular resolution (High Angular Resolution Diffusion Imaging, HARDI), using the constrained spherical deconvolution (CSD) algorithm for post-processing of data, makes it possible to avoid these disadvantages. Relatively recently, a new algorithm, Single-Shell 3-Tissue CSD (SS3TCSD), has been proposed for processing HARDI data, which has the potential to improve the reconstructing of pathways in the area of perifocal edema or edema-infiltration.Aim: To evaluate the potential of the new SS3TCSD algorithm compared to ST-CSD (Single-Tissue CSD) in the imaging of the optic radiation and visual tracts in patients with gliomas.Materials and methods: Diffusion and routine brain MRI was performed in 10 patients with newly diagnosed cerebral gliomas, followed by reconstruction of the optic radiation and visual tracts. We compared new algorithms for postprocessing MR tractography (ST-CSD and SS3TCSD) in imaging of the optic tract and visual radiation in patients with brain gliomas affecting various parts of the visual system.Results: The SS3T-CSD method showed a lower mean percentage of false positive tracts compared to the ST-CSD method: 19.75% for the SS3T-CSD method and 80.32% for the ST-CSD method in cases of proximity of the tumor to the tracts, 5.27% for the SS3T-CSD method and 25.27% for the STCSD method in cases of reconstructing tracts in healthy white matter.Conclusion: The SS3T-CSD method has a number of advantages over ST-CSD and allows for successful imaging of the optic pathways that have a complex structure and repeatedly change direction along their course.

Highlights

The use of magnetic resonance (MR) tractography in neurosurgery is becoming an increasingly common practice for noninvasive imaging of white matter pathways
Этих недостатков помогает избежать метод МР-трактографии, основанный на получении диффузионного изображения с высоким угловым разрешением с использованием алгоритма разложения по сферическим функциям для постобработки данных
All the authors have read and approved the final version of the manuscript before submission, agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved

Summary

Оригинальная статья

Относительно недавно был предложен новый алгоритм для обработки данных HARDI: разложение МР-сигнала нескольких типов ткани мозга по сферическим функциям с использованием одного b-фактора – SS3T-CSD (single-shell 3-tissue CSD). Цель – исследовать возможности алгоритма SS3T-CSD по сравнению с ST-CSD (single-tissue CSD – разложение МР-сигнала одного типа ткани мозга по сферическим функциям) при визуализации зрительной радиации и зрительных трактов у пациентов с глиомами. Мы сравнили новые алгоритмы постобработки МР-трактографии STCSD и SS3T-CSD при визуализации зрительных трактов и зрительной лучистости у пациентов с глиомами головного мозга, поражающими различные отделы зрительного анализатора. Multi-shell multi-tissue CSD, MSMT-CSD) [10] и разложение МР-сигнала нескольких типов ткани мозга по сферическим функциям с использованием одного b-фактора В связи с этим мы не стали изучать алгоритм MSMTCSD в нашей работе, но исследовали возможности нового алгоритма SS3T-CSD по сравнению с ST-CSD при визуализации зрительной радиации и зрительных трактов у пациентов с глиомами

Материал и методы

Ганглиоглиома Правая

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