Magnetic Resonance Spectroscopy: A Promise Detection of Metabolic Changes in the Brain of Intrauterine Growth Restriction Fetuses

Abstract

ABSTRACT Technical and therapeutic advances have driven the development of fetal MRI, which is likely to become an increasingly important modality in the evaluation of sonographically complex or occult anomalies of the fetal brain and body. All radiologists involved in prenatal imaging should be aware of the applications and limitations of this modality. Magnetic resonance imaging (MRI) studies have consistently demonstrated brain structural changes on intrauterine growth restriction (IUGR). There is a need to improve MRI characterization of the anatomical patterns of brain reorganization associated with IUGR and to develop specific imaging biomarkers. Contrary to acute perinatal events, IUGR is a chronic condition that induces brain reorganization and abnormal maturation rather than gross tissue destruction. Diffusion MRI offers a promising approach to assess abnormalities in brain maturation and develop biomarkers for clinical use. The association between IUGR and short- and long-term neurodevelopmental and cognitive dysfunctions has been extensively described. Preliminary clinical results suggest that diffusion MRI could also be suitable to detect maturational changes occurring in chronic fetal conditions, including fetal cardiac defects and IUGR. How to cite this article Zamfirescu V, Vladareanu R, Vladareanu S. Magnetic Resonance Spectroscopy: A Promise for Detection of Metabolic Changes in the Brain of Intrauterine Growth Restriction Fetuses. Donald School J Ultrasound Obstet Gynecol 2015;9(1):40-43.