Abstract
Water-soluble gadofullerene Gd@Ful with composition Gd3+@C82(OH)X3– (x ~ 20) was synthesized for theranostic study. Nanosuspensions of Gd@Ful were used for magnetic relaxation measurements in vitro and for magnetic resonance imaging of a rat with intracranially implanted C6 glioma. Gd@Ful was shown to reduce proton relaxation times in vitro and provide dual contrast of T1- and T2-weighted images in a rat brain tumor model after paramagnetic intravenous delivery. Magnetic relaxation times of water protons under action of Gd@Ful were strongly shortened due to cluster formation and increase of motional correlation times of protons in the vicinity of the fullerene cage. The Gd@Ful administration promoted the improvement of glioma contrast enhancement at T2-weighted images due to accumulation of paramagnetic substance at the tumor site. The contrast efficiency of Gd@Ful corresponds to the characteristics of negative contrast agent. The Gd@Ful nanosuspension is shown to be a contrast enhancer with high anti-tumor therapeutic potency. The retention of the Gd@Ful in the tumor resulted in a 75 % increase in survival times of the tumor-bearing animals.
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