Abstract
This study explores the hypothesis that Magnetic Resonance Imaging (MRI) can image the process of electrolysis by detecting pH fronts. The study has relevance to real time control of cell ablation with electrolysis. To investigate the hypothesis we compare the following MR imaging sequences: T1 weighted, T2 weighted and Proton Density (PD), with optical images acquired using pH-sensitive dyes embedded in a physiological saline agar solution phantom treated with electrolysis and discrete measurements with a pH microprobe. We further demonstrate the biological relevance of our work using a bacterial E. Coli model, grown on the phantom. The results demonstrate the ability of MRI to image electrolysis produced pH changes in a physiological saline phantom and show that these changes correlate with cell death in the E. Coli model grown on the phantom. The results are promising and invite further experimental research.
Highlights
This study explores the hypothesis that Magnetic Resonance Imaging (MRI) can image the process of electrolysis by detecting pH fronts
To investigate the hypothesis we compare the following MR imaging sequences: T1 weighted, T2 weighted and Proton Density (PD), with optical images acquired using pH-sensitive dyes embedded in a physiological saline agar solution phantom treated with electrolysis and discrete measurements with a pH microprobe
The results demonstrate the ability of MRI to image electrolysis produced pH changes in a physiological saline phantom and show that these changes correlate with cell death in the E
Summary
This study explores the hypothesis that Magnetic Resonance Imaging (MRI) can image the process of electrolysis by detecting pH fronts. This work was inspired by several findings and the development of a few research techniques: it was shown that the electrolysis induced pH changes can be used to reliably monitor the extent of tissue ablation[19]. These findings have led to several basic studies on quantifying the process of electrolysis through the use of transparent gels with pH dyes[11,20,21]. The primary goal of this study is to explore the hypothesis that pH fronts, produced by electrolysis, can be detected with MRI, for possible application in monitoring and controlling cell ablation with electrolysis. Inspired by references[30,38], we chose to explore our hypothesis with basic T1 weighted and T2 weighted based sequences for water
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