Abstract
ObjectiveThis research aims to investigate magnetic resonance imaging (MRI) in the tibial epiphyseal growth plate development of Wistar rat.MethodsFifty weanling Wistar rats were divided by a computerized blocking procedure into five groups. The rats received standard commercial feed with or without T-2 toxin additive, low-protein feed with or without T-2 toxin additive, and Kashin–Beck disease (KBD)-affected feed.ResultsCompared with the control group rat, MRI showed localized epiphyseal plate swelling, rough appearance, and uneven signal on the tibia of rats fed with KBD-affected feed. Histology confirmed the epiphyseal plate degeneration seen by MRI, and the degenerative changes were characterized by abnormal distribution of chondrocytes with loss and clustering, cartilage fragmentation, and erosion in group E.ConclusionsThe MR image of the rat epiphyseal plate is altered in the KBD model rats, and epiphyseal plate MRI appearance has been reproduced by using T-2 toxin and KBD-affected feed of epidemic district.
Highlights
Magnetic resonance imaging (MRI) is extensively used for the evaluation and examination of various kinds of tissues in medicine and dentistry because it produces high-quality images of the soft tissues without ionizing radiation [1]
It is clear that Kashin–Beck disease (KBD) usually involves the metaphysis in a growing bone and etiology shows that low T-2 toxin average intake is a major causative agent of KBD, there are few studies about this in the literature, and more studies in animal models are needed to demonstrate the pathogenesis of low T-2 toxin average intake in KBD [19,20,21,22]
In vivo MRI was undertaken on the hind knee of Wistar rats which had been fed with KBD-affected feed and T-2 toxin to investigate epiphyseal plate developmental biology and pathogenesis
Summary
Magnetic resonance imaging (MRI) is extensively used for the evaluation and examination of various kinds of tissues in medicine and dentistry because it produces high-quality images of the soft tissues without ionizing radiation [1]. The ability of T-2 toxin to produce necrosis of the epiphyseal plate cartilage tissue, including pronounced DNA and decreased numbers of chondrocytes, is well documented [16,17], little is presently known about the epiphyseal plate developmental biology of this mycotoxin in Wistar rat with low T-2 toxin average intake [25]. No paper investigating the epiphyseal plate of rats which have been fed with KBD-affected feed and those with low T-2 toxin average intake has been published. In vivo MRI was undertaken on the hind knee of Wistar rats which had been fed with KBD-affected feed and T-2 toxin to investigate epiphyseal plate developmental biology and pathogenesis
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