Abstract
BackgroundCommon cancerous histological types associated with endometriosis are clear cell carcinoma (CCC) and endometrioid carcinoma (EC). CCC is regarded as an aggressive, chemoresistant histological subtype. Magnetic resonance imaging (MRI) offers some potential advantages to diagnose ovarian tumors compared with ultrasonography or computed tomography. This study aimed to identify MRI features that can be used to differentiate between CCC and EC.MethodsWe searched medical records of patients with ovarian cancers who underwent surgical treatment at Nara Medical University Hospital between January 2008 and September 2018; we identified 98 patients with CCC or EC who had undergone preoperative MRI. Contrasted MRI scans were performed less than 2 months before surgery. Patients were excluded from the study if they had no pathology, other pathological subtype of epithelial ovarian cancer, and/or salvage treatment for recurrence and metastatic ovarian cancer at the time of study initiation. Clinically relevant variables that were statistically significant by univariate analysis were selected for subsequent multivariate regression analysis to identify independent factors to distinguish CCC from EC.ResultsMRI of CCC and EC showed a large cystic heterogeneous mixed mass with mural nodules protruding into the cystic space. Univariate logistic regression analysis revealed that the growth pattern (broad-based nodular structures [multifocal/concentric sign] or polypoid structures [focal/eccentric sign]), surface irregularity (a smooth/regular surface or a rough/irregular/lobulated surface), “Width” of mural nodule, “Height-to-Width” ratio (HWR), and presence of preoperative ascites were factors that significantly differed between CCC and EC. In the multivariate logistic regression analysis, the growth pattern of the mural nodule (odds ratio [OR] = 0.69, 95% confidence interval [CI]: 0.013–0.273, p = 0.0004) and the HWR (OR = 3.71, 95% CI: 1.128–13.438, p = 0.036) were independent predictors to distinguish CCC from EC.ConclusionsIn conclusion, MRI data showed that the growth pattern of mural nodules and the HWR were independent factors that could allow differentiation between CCC and EC. This finding may be helpful to predict patient prognosis before operation.
Highlights
Common cancerous histological types associated with endometriosis are clear cell carcinoma (CCC) and endometrioid carcinoma (EC)
There were no significant differences between the CCC and EC groups in variables such as age, body mass index (BMI), parity, menopausal status, clinical stage, or International Federation of Gynecology and Obstetrics (FIGO) stage
The imaging findings associated with tumor characteristics on Magnetic resonance imaging (MRI) were compared between the two groups via univariate analysis (Table 2)
Summary
Common cancerous histological types associated with endometriosis are clear cell carcinoma (CCC) and endometrioid carcinoma (EC). Magnetic resonance imaging (MRI) offers some potential advantages to diagnose ovarian tumors compared with ultrasonography or computed tomography. Ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI) have been established as useful tools in the multimodality approach to detect, characterize, and diagnose ovarian tumors [1]. MRI offers the following potential advantages compared with the other modalities: lack of ionizing radiation exposure relative to CT, higher contrast resolution, higher specificity, greater accuracy, more reliable and reproducible measurements, and good inter-observer agreement for identification of malignant ovarian lesions [2]. Characteristic features of epithelial ovarian cancer include the presence of the following: a cystic mixed mass (complex solid and cystic), varying proportions of a solid-enhancing component, a mural nodule or papillary projection and internal thick septation, central necrosis, tumor vascularity, ascites, peritoneal implants, and lymph node enlargement [10, 11]
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