Abstract

Surgical treatment for psychiatric disorders, such as obsessive-compulsive disorder (OCD) and depression, using ablative techniques, such as cingulotomy and capsulotomy, have historically been controversial for a number of scientific, social, and ethical reasons. Recently, with the elucidation of anatomical and neurochemical substrates of brain function in healthy controls and patients with such disorders using various functional neuroimaging techniques, these criticisms are becoming less valid. Furthermore, by using new techniques, such as deep brain stimulation (DBS), and identifying more precise targets, beneficial effects and the lack of serious complications have been demonstrated in patients with psychiatric disorders. However, DBS also has many disadvantages. Currently, magnetic resonance-guided focused ultrasound surgery (MRgFUS) is used as a minimal-invasive surgical method for generating precisely placed focal thermal lesions in the brain. Here, we review surgical techniques and their potential complications, along with anterior limb of the internal capsule (ALIC) capsulotomy by radiofrequency lesioning and gamma knife radiosurgery, for the treatment of OCD and depression. We also discuss the limitations and technical issues related to ALIC capsulotomy with MRgFUS for medically refractory OCD and depression. Through this review we hope MRgFUS could be considered as a new treatment choice for refractory OCD.

Highlights

  • Obsessive-compulsive disorder (OCD) is a mental disorder characterized by time-consuming, distressing obsessions and/or compulsions [1]

  • We provide an overview of the history of surgery for psychiatric disorders and discuss the latest surgical options for psychiatric disorders, with a focus on OCD

  • In 1949, Talairach first introduced the technique of anterior capsulotomy to disconnect fibers from the orbitofrontal cortex leading to the limbic system that pass through the anterior limb of the internal capsule (ALIC) for patients with psychiatric disorders [17]

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Summary

Introduction

Obsessive-compulsive disorder (OCD) is a mental disorder characterized by time-consuming, distressing obsessions and/or compulsions [1]. In our institute’s series regarding cingulotomy for OCD [28, 41], 17 patients had a Y-BOCS score of 35.0 ± 3.86 preoperatively and showed a mean improvement of 48% over the baseline score after a follow-up period of at least 2 years. In a recent long-term study with a 5-year mean follow-up period in 64 patients, Sheth et al [42] showed a 47% rate of full response (more than 35% improvement in the Y-BOCS score).

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