Abstract
Magnetic Resonance Elastography (MRE) technique has been developed in order to quantify the mechanical and assess the morphological properties of different skeletal muscles. In this chapter, the experimental setup for MRE of muscle, the MRE sequence as well as the image processing and data analysis will be described. A database of healthy and pathological muscle stiffness represented with cartographies at different conditions (passive and active) and as a function of age (children, adult, and senior) has been established. In order to understand the mechanical properties of the muscle, stiffness parameter and the attenuation coefficient of the shear wave were also analyzed. A comparative evaluation of MRE with ultrasound was also performed in the same area as the shear wave’s propagation demonstrating the capacity of the MRE technique to reflect the muscle architecture. To further characterize the micro structural changes occurring in muscle tissue, the viscoelastic (μ, η) properties of the muscles as well as the subcutaneous adipose tissue were determined with multifrequency MRE tests and different rheological models (Voigt, Zener, and springpot). MRE is a promising technique for evaluating skeletal muscle non-invasively and clinical applications of MRE of muscle may soon emerge.
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