Magnetic Resistance Sensory System for the Quantitative Measurement of Morphine.

Abstract

Point-of-care testing (POCT) is characterized by fast detection, simple use, and cost efficiency. As the focus of healthcare shifts to precision medicine, population health, and chronic disease management, the potential impact of POCT has increased significantly in the past decade. Immunochromatographic test strips (ICTSs) are currently the most promising POCT diagnostic format due to the advantages of fast detection, simple operation and cost-effective. The lateral flow immune analyzer (LFIA) system that uses magnetic resistance (MR) sensors as readers and magnetic nanoparticle labeling materials has attracted wide attention due to its high sensitivity and specificity. This paper designs a quantitative lateral flow immunoassay instrument for MR sensors using InSb single crystals as magnetoresistive elements. MR sensors detect samples of ICTSs labeled with superparamagnetic nanoparticles (SMNPs). The collected weak magnetic signal is processed by the designed amplifying circuit and software algorithm. As a result, the MR system can quantitatively detect the concentration of morphine (MOP), and has good repeatability. Compared with other optical detection instruments, the system has good specificity because there is very low background noise in the detection sample. The size of the whole system is [Formula: see text], and it has the characteristics of compactness and fast detection.