Abstract
The current study emphasizes the synthesis of iron oxide nanoparticles (IONPs) and impact of hydrophilic polymer polyvinyl alcohol (PVA) coating concentration as well as anticancer drug doxorubicin (DOX) loading on saturation magnetization for target drug delivery applications. Iron oxide nanoparticles particles were synthesized by a reformed version of the co-precipitation method. The coating of polyvinyl alcohol along with doxorubicin loading was carried out by the physical immobilization method. X-ray diffraction confirmed the magnetite (Fe3O4) structure of particles that remained unchanged before and after polyvinyl alcohol coating and drug loading. Microstructure and morphological analysis was carried out by transmission electron microscopy revealing the formation of nanoparticles with an average size of 10 nm with slight variation after coating and drug loading. Transmission electron microscopy, energy dispersive, and Fourier transform infrared spectra further confirmed the conjugation of polymer and doxorubicin with iron oxide nanoparticles. The room temperature superparamagnetic behavior of polymer-coated and drug-loaded magnetite nanoparticles were studied by vibrating sample magnetometer. The variation in saturation magnetization after coating evaluated that a sufficient amount of polyvinyl alcohol would be 3 wt. % regarding the externally controlled movement of IONPs in blood under the influence of applied magnetic field for in-vivo target drug delivery.
Highlights
Drug loaded nanoparticles (NPs) based cancer therapy possesses the potential to overcome the toxicity of the drug and its poor control on dosing when custom combination therapies are PLOS ONE | DOI:10.1371/journal.pone.0158084 June 27, 2016Effect of polyvinyl alcohol (PVA) and DOX on Ms of iron oxide nanoparticles (IONPs) for Drug Delivery Applications employed [1,2,3,4]
The main goal and novelty of the present work is to conjugate the DOX with PVA coated (3 and 6wt%) iron oxide nanoparticle carriers to study the magnetic behavior for in-vivo target drug delivery and to speculate judiciously the maximum concentration of PVA related to evaluation of saturation magnetization that would be necessary for the controlled movement of IONPs in blood under the influence of applied magnetic field
Superparamagnetic IONPs suspensions in ultra-pure water were prepared with an effective and simple scheme employed in reformed co-precipitation method
Summary
Drug loaded nanoparticles (NPs) based cancer therapy possesses the potential to overcome the toxicity of the drug and its poor control on dosing when custom combination therapies are PLOS ONE | DOI:10.1371/journal.pone.0158084 June 27, 2016Effect of PVA and DOX on Ms of IONPs for Drug Delivery Applications employed [1,2,3,4].
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