Magnetic nanoparticles preparation by chemical reduction for biomedical applications

Zhazgul Kelgenbaeva,Ruslan Adil Akai Tegin,Begimzhan Dyusheeva,Janbolot Aidaraliev,Elmira Murzabekova,Bektemir Murzubraimov,Artem Kozlovsky,Ainur Turdubai Kyzy,I Bobrikov,A Friesen,O Derenovskaya,A Verkheev,V Chudoba

doi:10.1051/epjconf/201920101002

Abstract

This work presents Fe3O4 and AgFe nanoparticles with an average diameter of 25 and 15 nm synthesized by chemical reduction of corresponding salts under a mild condition. Cubic crystal structure and spherical shape of the nanoparticles were studied by X-ray diffraction, Field emission SEM and energy-dispersive spectroscopy analysis. For biomedical applications, the nanoparticles were tested against bacteria E.coli and results revealed AgFe nanoparticles’ antibacterial activity by forming lysis zone in scale of 0.5 mm.

Highlights

Magnetic nanoparticles have been extensively studied in the past half century and continue to maintain interest because of their potential use in areas ranging from storage of high-density data to biomedical applications [1]
The following objectives were set to achieve the goal: 1) synthesis of magnetite and AgFe nanoparticles by reduction of their corresponding salts under a mile conditions using hydrazine hydrate as a reducing agent; 2) to study the physicochemical properties and biological activities of synthesized nanoparticles
X-ray diffraction (XRD) pattern of Fe-system sample obtained by chemical reduction of FeSO4 *7H2O using N2H4 as reducing agent presented in Figure 1 shows, that the sample is monophasic Fe3O4 with phase content of 100%

Summary

Introduction

Magnetic nanoparticles have been extensively studied in the past half century and continue to maintain interest because of their potential use in areas ranging from storage of high-density data to biomedical applications [1]. Monodispersed magnetite (Fe3O4) nanoparticles have given a new impetus in the application field where magnetic nanoparticles are extensively used in Ferro fluids, biological imaging and therapies [2, 3]. Magnetic bimetallic Fe-Ag nanoparticles exhibit significant antibacterial and antifungal activities against variety of microorganisms; they have numerous applications in optical, medical and remediation fields [4]. The aim of this work is to prepare magnetic Fe3O4 and bimetallic AgFe nanoparticles for biomedical applications. The following objectives were set to achieve the goal: 1) synthesis of magnetite and AgFe nanoparticles by reduction of their corresponding salts under a mile conditions using hydrazine hydrate as a reducing agent; 2) to study the physicochemical properties and biological activities of synthesized nanoparticles

Objectives

Results

Conclusion