Abstract
Magnetic nanoparticles for peripheral nervous system regeneration
Highlights
Neuronal regeneration represents one of the most actual scientific research topic [1], as peripheral nervous system lesions have a high incidence, are often disabling and represent an important social cost.Nowadays the gold standard treatment for losses of nervous substance is still the autologous nervous graft
The current study has demonstrated that magnetic nanoparticles (MNPs), after neuronal internalisation and under an external magnetic field, can develop a minimal tensile force that is controllable and is able to favor axonal growth and to direct it in the same direction of the magnetic field
The preliminary phase of this study aims to evaluate the behavior of MNPs inside the nervous gap
Summary
Nowadays the gold standard treatment for losses of nervous substance is still the autologous nervous graft. The success of this treatment is due to the presence of Schwann cells, who can recall the growing neuron and to create a microhabitat ideal for neuronal regeneration [2]. Bioengineering research has focused on neuronal guides as an alternative to biological grafts. Neuronal guides work as stiff support imitating the structure of extracellular matrix (ECM) [9,10] and limiting the loss of growth factors and the local infiltration of scarring tissue [11]
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