Magnetic nanoparticles based on cerium MOF supported on the MWCNT as a fluorescence quenching sensor for determination of 6-mercaptopurine

Abstract

In this study, a new magnetic nanocomposite was developed as an efficient and fast-response fluorescence quenching sensor for determination of anticancer drug 6-mercaptopurine (6-MP). For this purpose, the needle-shape fluorescence metal-organic framework of cerium (Ce-MOF) were successfully synthesized on the surface of multiwalled carbon nanotubes using 1,3,5-benzenetricarboxylic acid ligand via a facile solvothermal assisted route and magnetized. The accuracy of the proposed synthesis was confirmed using the FT-IR, FE-SEM, XRD, and VSM methods. The obtained product as presented the fluorescence emission in 331 nm by excitation of 293 nm in excitation/emission slit widths of 10.0 nm. The operation of suggested method is based on quenching the fluorescence signal in accordance with increasing the 6-MP concentration. The proposed assay effectively detected the trace amount of 6-MP in the linear range of 1.0 × 10−6 to 7 × 10−5 M. The limit of detection and limit of quantification were obtained as 8.6 × 10−7 and 2.86 × 10−6 M, respectively. The analyte molecule was determined in real samples with satisfactory recoveries between 98.75 and 105.33.