Abstract
In the present study, the author describe a method for magnetic solid phase extraction (MSPE) combined with ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for the quantitation of seven non-steroidal anti-inflammatory drugs (NSAIDs) in environmental water samples. Core-shell Fe3O4@MIL-100(Fe) as the adsorbent in the MSPE was novelly synthesized and successfully applied for the first time. Several experimental parameters, including the effect of pH value of aqueous solution, the amount of the adsorbent, ionic strength, adsorption time, desorption solvent and its volume, and desorption time, were investigated. Under the optimal conditions, the linear ranges were 0.1–10 µg L−1 for meloxicam, carprofen, indometacin, and tolfenamic acid, 0.2–20 µg L−1 for diclofenac, and 0.3–30 µg L−1 for naproxen and mefenamic acid with the regression coefficients (r) from 0.9987 to 0.9995, respectively. The limits of detection were between 0.02 and 0.09 µg L−1. The method also exhibited excellent precision (RSD ≤ 9.6%), repeatability (RSD ≤ 9.3%), and recovery (75.2–105.2%). The method presented the advantages of simplicity, rapidly, less solvent consumption, and higher sensitivity. It's promising for the core-shell Fe3O4@MIL-100(Fe) to be used as the adsorbent of MSPE for detecting and removing residues in the environment.
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