Abstract
Magnetic resonance imaging (MRI) probes are the important tools for discovering small pathological changes with functionality analysis. Probe structural design, functionality, multimodality, and applications will be covered in this talk. The focus of probe structural design is mainly aimed on how to improve the imaging sensitivity, including one important feature: the relaxivity of probes. Superparamagnetic nanoparticles are efficient proton enhancers. In our approach, magnetic nanoparticles are usually delivered by polymeric carriers with improved biocompatibility and sensitivity. Design of small moleucle paramagnetic probes and conjugation to polymeric carriers will also be discussed. Short BIOGRAPHY Hua Ai, PhD, Professor of Biomaterials, National Engineering Research Center for Biomaterials, Sichuan University. Dr. Ai is focusing on design and applications of nanobiomaterials for molecular imaging and drug delivery. He has developed ultrasensitive MRI probes based on self-assembly of amphiphilic polymers and magnetic nanocrystals. His work has been published on academic journals including Acc Chem Res, Adv Drug Deliv Rev, Adv Mater, Biomaterials, Nano Letters, Small, J Control Release, etc. Dr. Ai is in the editorial boards of Biomaterials, BioNanoScience, J Pharm Sci, and Pharmaceutical Nanotechnology. Dr. Ai is the current Secretary-General of Chinese Society for Biomaterials (www.csbm.org.cn).
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