Abstract
When using magnetic nanoparticles as a heating source for magnetic particlehyperthermia it is of particular interest to know if the particles are free to movein the interstitial fluid or are fixed to the tumour tissue. The immobilizationstate determines the relaxation behaviour of the administered particles and thustheir specific heating power. To investigate this behaviour, magnetic multicorenanoparticles were injected into experimentally grown tumours in mice andmagnetic heating treatment was carried out in an alternating magnetic field (H = 25 kA m − 1,f = 400 kHz). The tested particles were well suited for magnetic heating treatment as they heated atumour of about 100 mg by about 22 K within the first 60 s. Upon sacrifice, histologicaltumour examination showed that the particles form spots in the tissue with a mainlyhomogeneous particle distribution in these spots. The magnetic ex vivo characterizationof the removed tumour tissue gave clear evidence for the immobilization of theparticles in the tumour tissue because the particles in the tumour showed the samemagnetic behaviour as immobilized particles. Therefore, the particles are not able torotate and a temperature increase due to Brown relaxation can be neglected. Toaccurately estimate the heating potential of magnetic materials, the respectiveenvironments influencing the nanoparticle mobility status have to be taken into account.
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