Abstract
Many types of fluorescent nanoparticles have been investigated as alternativesto conventional organic dyes in biochemistry; magnetic beads also have a longhistory of biological applications. In this work we apply flame spray pyrolysis inorder to engineer a novel type of nanoparticle that has both luminescent andmagnetic properties. The particles have magnetic cores of iron oxide doped withcobalt and neodymium and luminescent shells of europium-doped gadolinium oxide(Eu:Gd2O3). Measurements by vibrating sample magnetometry showed an overall paramagnetic response ofthese composite particles. Luminescence spectroscopy showed spectra typical of the Eu ion in aGd2O3 host—a narrow emission peak centred near 615 nm. Our synthesis method offers a low-cost,high-rate synthesis route that enables a wide range of biological applications ofmagnetic/luminescent core/shell particles. Using these particles we demonstrate anovel immunoassay format with internal luminescent calibration for more precisemeasurements.
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