Abstract
Non-invasive removal of thrombosis is a difficult problem in clinical vascular disease. Herein, we reported magnetic hyperthermia combined photothermal therapy for celiac vein thrombosis using Fe3S4 nanoparticles as thrombolytic agents under the stimulation of a near infrared (NIR) laser and an external alternating magnetic field (AMF). Fe3S4 nanoparticles showed excellent magnetothermal conversion performance under the continuous stimulation of an AMF and very good photothermal conversion performance under the irradiation of a NIR laser. Moreover, Fe3S4 nanoparticles exhibited a synergistic thermal conversion effect under the co-stimulation of NIR and AMF. In addition, the Fe3S4 nanoparticles possess the ability for magnetic resonance (MR) imaging with the transverse relaxivity (r2) is up to 53.1 mM−1 s−1. Finally, we, for the first time, proved the Fe3S4 nanoparticles as a promising thrombolytic agent for both photothermal thrombolytic capacity and magnetothermal thrombolytic ability. Our work provides the insight of hyperthermia for removal of the thrombosis.
Highlights
Cardiovascular disease is one of the main causes of harm to human health (Mackman, 2008; Engelmann and Massberg, 2013)
Magnetic hyperthermia is a way in which a magnetothermal conversion reagent generates heat to treat a disease under the action of an external alternating magnetic field (AMF) (Wang F. et al, 2017; Li et al, 2018; Dai et al, 2019)
It has been revealed that Fe3S4 nanoparticles have a very good magnetocaloric effect which could be used in magnetic hyperthermia for deep thrombosis (Guan et al, 2018; Moore et al, 2019)
Summary
Cardiovascular disease is one of the main causes of harm to human health (Mackman, 2008; Engelmann and Massberg, 2013). Magnetic hyperthermia is a way in which a magnetothermal conversion reagent generates heat to treat a disease under the action of an external alternating magnetic field (AMF) (Wang F. et al, 2017; Li et al, 2018; Dai et al, 2019). It has been revealed that Fe3S4 nanoparticles have a very good magnetocaloric effect which could be used in magnetic hyperthermia for deep thrombosis (Guan et al, 2018; Moore et al, 2019). Fe3S4 nanoparticles show great potential for the magnetic hyperthermia for deep thrombosis. We reported hyperthermia for celiac vein thrombosis using Fe3S4 nanoparticles as a thrombolytic reagent under the stimulation of a NIR laser and an AMF. We, for the first time, proved the Fe3S4 nanoparticles as a promising thrombolytic agent for magnetic hyperthermia for celiac vein thrombosis
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