Abstract
BackgroundThe major therapy for ischemic stroke is thrombolytic treatment, but severe consequences occur when this method is used to treat hemorrhagic stroke. Currently, computed tomography and magnetic resonance imaging are used to differentiate between two types of stroke, but these two methods are ineffective for pre-hospital care.MethodsWe developed a new brain diagnostic device for rabbits based on electromagnetic induction to non-invasively differentiate two types of stroke. The device includes two coils and a phase difference measurement system that detects the magnetic inductive phase shift (MIPS) value to reflect the tissue’s condition. The hemorrhage model was established through the injection of autologous blood into the internal capsule of a rabbit’s brain. Ischemia was induced in the brain of a rabbit by bilateral carotid artery occlusion. Two types of animal models were measured with our device.ResultsThe MIPS value gradually decreased with increasing injected blood and increased with ischemia time. The MIPS changes induced by the two types of strokes were exact opposites, and the absolute values of MIPS variation in the hemorrhagic and the ischemic groups were significantly larger than those of the normal control group (P < 0.05).ConclusionsThe tested technique can differentiate ischemic stroke from hemorrhagic stroke on rabbit brain in a non-invasive, continuous, and bulk monitoring manner by using a simple and inexpensive apparatus.
Highlights
The major therapy for ischemic stroke is thrombolytic treatment, but severe consequences occur when this method is used to treat hemorrhagic stroke
For the result of each animal in hemorrhage group, the magnetic inductive phase shift (MIPS) data during 1-h injection were separated into 21 successive parts
A novel coil structure based on MIPS technology was tested to distinguish between ischemic stroke and hemorrhagic stroke
Summary
The major therapy for ischemic stroke is thrombolytic treatment, but severe consequences occur when this method is used to treat hemorrhagic stroke. The latest statistics issued by the Ministry of Health of the People’s Republic of China reveal that stroke is the first cause of death among all diseases in China, and its standardized mortality rate in the country ranks first in the world. Such a mortality rate continues to increase at a yearly rate of 9%. 2 million people suffer a stroke each year. Among this population, nearly half die, and roughly 3/4 of the survivors experience varying degrees of
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