Magnetic hyperthermia cancer therapy using rare earth metal-based nanoparticles: An investigation of Lanthanum strontium Manganite's hyperthermic properties

Abstract

Magnetic hyperthermia cancer therapy has emerged as a promising approach for targeted and localized treatment of cancer. This innovative technique utilizes magnetic nanoparticles to generate localized heat within tumor cells, leading to their selective destruction. This study explores the hyperthermic potential of Lanthanum Strontium Manganite (LSMO), which are rare earth metal-based magnetic nanoparticles, for their application in magnetic hyperthermia cancer therapy. A modified citrate sol-gel technique was utilized to create LSMO (La0·7Sr0·3MnO3) nanoparticles, which were then modified by coating with silica. Comprehensive physical characterization of the nanoparticles was performed, and their hyperthermic potential was evaluated in vitro. The biocompatibility and selective cytotoxicity of LSMO nanoparticles were investigated, and the results demonstrated promising outcomes. With its controlled and localized heat generation and enhanced biocompatibility, LSMO offers an encouraging avenue for advancing targeted and effective cancer treatments. Future research in this field may pave the way for transformative improvements in cancer therapy outcomes.