Magnetic Hercules Swarm for Precise and Effective Deep Biofilm Eradication

Abstract

AbstractOver the past decade, significant advancements in micro‐nano robots have enabled non‐invasive operations in hazardous, confined environments, particularly targeting persistent bacterial biofilms in hard‐to‐reach areas. However, many of these robots are limited by poor magnetic properties, hindering their effectiveness against biofilms. This study proposes a novel strategy using a swarm with strong magnetic effects (Hercules swarm) combined with near‐infrared (NIR) light for effective biofilm eradication. Carbonyl iron particles coated with polydopamine (CI@PDA), averaging ≈3 µm in diameter, demonstrate clustering and significant magneto‐force under a rotating magnetic field due to their large magnetic saturation. This enables the Hercules swarm to achieve rapid delivery (100 mm s−1), efficient cargo transport (carrying twice its own weight), and effective catheter clearance (1 mm min−1). The controllable motion and high photothermal activity enable precise biofilm eradication without toxic agents. The aggregation of magnetic particles into chains and their rotation are explored by improved particle dynamic model. Simulations also reveal enhanced fluid convection and mechanical pressure around the particle chain. Due to its easy operation, straightforward controllability, and environmental compatibility, the magnetic Hercules swarm emerges as a promising treatment modality for eliminating biofilms entrenched within intricate, narrow, and convoluted medical implants or industrial conduits.