Magnetic fluid hyperthermia controlled by frequency counter and colorimetric program systems based on magnetic nanoparticles

Abstract

Magnetic nanoparticles (MNP) are anticipated to perform better in terms of thermal conductivity when exposed to alternating magnetic fields (AMF). Herein, key parameters for efficient heating are examined in an AMF that is organized and managed by a zero voltage switching (ZVS) and frequency counter system, which has shown great potential for hyperthermia (HT). The present study investigates the set-up of a matched coil coupled with direct current (DC) power and a frequency counter. The set-up technique for inducing HT in magnetic fluid NPs used in in vitro experiments and magnetic fluid calorimetric applications is advanced. Superparamagnetic iron oxide nanoparticles Fe3O4 (SPIONs) was prepared by the sonochemical method and coated with polyethylene glycol (Fe3O4@PEG). Our sample Fe3O4@PEG crystallized nano-size with an average particle size of 14 nm, and high magnetic saturation (MS) about 49 emu/g. The MNPs exposed to AMF at 300 kHz exhibited the highest thermal values (42–45 °C). The specific absorption rate values of 188, 217, and 234 W/g for the NP concentrations of 5, 10, and 20 mg/ml, respectively reveal the improvement of our set-up to enhance the SPIONs as a thermal agent.