Abstract
Photon counts were measured every 15 ms for 75 s from microtubule-enriched preparations (and nuclei) from mouse melanoma cells during baseline and after 2 min exposures to 1 μT magnetic fields. The magnetic fields were generated from a circular array of solenoids and presented with accelerating or decelerating rotation velocities. The range of photon radiant flux density was in the order of 10-12 W·m-2. Microtubules preparations that had been exposed for only 2 min to a magnetic field configuration corresponding to the electric field pattern that induced long-term potentiation in neural tissue when applied as electric current displayed peaks of spectral power densities within 7 - 8 Hz, 9.5 Hz, 14 - 15 Hz, and 22 Hz bands. The major peak (9.4 Hz) bandwidth was approximately 0.1 Hz. While microtubule preparations exposed for 2 min to a 7 Hz sine-wave or in the absence of a field emitted an overall similar level of spectral power density, the peaks in power density were not present. Treatment with the LTP patterned fields, compared to the baseline or sine-wave fields primarily altered the frequency band in which the amplitude of the photon field was expressed. These results suggest that the photon emissions from microtubule preparations have the capacity to respond to specifically-patterned or geometric shapes of magnetic fields by altering spectral configurations rather than the absolute numbers of photons.
Highlights
Whereas the functions of the molecular components of the cell respond to spatial structures of atoms, the electromagnetic functions of the cell appear to respond to temporal patterns of energy
The means and standard deviations for the numbers of photon counts per 15 ms were 0.6 (0.1) for the air, 10.6 (10.2) for the baseline, 7.4 (5.2) for microtubule preparations after the modified Long-Term Potentiation (LTP) pattern, and 5.1 (2.9) after the 7 Hz sine wave exposure
The shift in the power density compared to baseline conditions was conspicuous for the fast-frequency component of the magnetic field pattern that when applied as current produces long-term potentiation in hippocampal slices
Summary
Whereas the functions of the molecular components of the cell respond to spatial structures of atoms, the electromagnetic functions of the cell appear to respond to temporal patterns of energy. Long-Term Potentiation (LTP) is a powerful process [1] within neuronal aggregates within the hippocampus and other brain regions by which representations of stimuli (experience) are facilitated to form spatial representations within the spine patterns of dendrites [2] The consequence of this process is that less energy is required to evoke the complimentary representation when a similar stimulus pattern is presented again. A single reaction involving a quantum of energy in the order of 10−20 J [4] per molecule was associated with a long-term shift in the state of responsiveness of the cell Rose and his colleagues [5] found that a temporal pattern of electric current associated with a single priming pulse followed 150 ms later by four rapid pulses (equivalent to ~100 Hz) resulted in significant LTP when applied to hippocampal slices. When this pattern was transformed to weak magnetic fields in the order of 1 μT and applied to the entire animal before learning a spatial task, the disruption of the memory was as powerful as complete depolarization of the hippocampal region by direct current [6]
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