Abstract
Major progress in the field of regenerative medicine is expected from the design of artificial scaffolds that mimic both the structural and functional properties of the ECM. The bionanocomposites approach is particularly well fitted to meet this challenge as it can combine ECM-based matrices and colloidal carriers of biological cues that regulate cell behavior. Here we have prepared bionanocomposites under high magnetic field from tilapia fish scale collagen and multifunctional silica nanoparticles (SiNPs). We show that scaffolding cues (collagen), multiple display of signaling peptides (SiNPs) and control over the global structuration (magnetic field) can be combined into a unique bionanocomposite for the engineering of biomaterials with improved cell performances.
Highlights
Bionanocomposites include different types of materials with common features that are the combination of elements of different chemical nature, one being of biological origin
While this may include biological or synthetic polymers [3], we focus here on type I collagen, which is of particular relevance for designing biomimetic extracellular matrices (ECMs) as it is a major constituent of connective tissues [4,5]
We report here the design of bionanocomposites from tilapia fish scale collagen and functionalized silica nanoparticles (SiNPs) prepared under high magnetic field
Summary
Bionanocomposites include different types of materials with common features that are the combination of elements of different chemical nature, one being of biological origin. Previous works showed the possibility to tune the orienting effect of magnetic field throughout the anisotropic hydrogel over a given fibrillogenic period, playing with temperature, collagen concentration and magnetic strength [15,16]. Twenty years after their discovery, Torbet et al successfully oriented magnetically collagen fibrils to develop an assembled plywood structure as an artificial scaffold for corneal transplantation [17]. Magnetically-oriented ECM-like materials find a high relevance in biomedical research given that aligned collagen scaffolding is one feature of the tumor ECM [22,23]
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