Magnetic chitosan microgels: Synthesis, characterization, and evaluation of magnetic field effect over the drug release behavior

Abstract

Magnetic microgels based on chitosan, modified with glycidyl methacrylate (GMA) and activated with folic acid (FA), and cobalt ferrite nanoparticles, modified with GMA (GMACoFe2O4), were synthesized by emulsion polymerization. The size of the round-shaped microgels, with and without GMACoFe2O4, ranged from (1.62 ± 0.38) μm to (1.71 ± 0.61) μm, respectively. Their release behavior was evaluated in the presence and absence of a magnetic field (MF), using vitamin-B12 as a model drug. In the absence of MF, at pH 7.4, a fast release was observed, reaching the equilibrium after 30 min. In the MF presence, the alignment of the chains to it promoted an initial fast release, followed by a more controlled one, lasting for 50 min at pH 7.4. This type of release is attractive for the treatment of gastric wounds, which is improved by the presence of FA, conferring anti-oxidative and anti-secretory properties to the microgels.