Magnetic Characterization and Moderate Cytotoxicity of Magnetic Mesoporous Silica Nanocomposite for Drug Delivery of Naproxen.

Adriana Zeleňáková,Vladimír Girman,Jaroslava Szűcsová,Ľuboš Nagy,Vladimír Zeleňák,Veronika Huntošová

doi:10.3390/nano11040901

Abstract

In this study, we describe the magnetic and structural properties and cytotoxicity of drug delivery composite (DDC) consisting of hexagonally ordered mesoporous silica, iron oxide magnetic nanoparticles (Fe2O3), and the drug naproxen (Napro). The nonsteroidal anti-inflammatory drug (NSAID) naproxen was adsorbed into the pores of MCM-41 silica after the ultra-small superparamagnetic iron oxide nanoparticles (USPIONs) encapsulation. Our results confirm the suppression of the Brownian relaxation process caused by a “gripping effect” since the rotation of the whole particle encapsulated in the porous system of mesoporous silica was disabled. This behavior was observed for the first time, to the best of our knowledge. Therefore, the dominant relaxation mechanism in powder and liquid form is the Néel process when the rotation of the nanoparticle’s magnetic moment is responsible for the relaxation. The in vitro cytotoxicity tests were performed using human glioma U87 MG cells, and the moderate manifestation of cell death, although at high concentrations of studied systems, was observed with fluorescent labeling by AnnexinV/FITC. All our results indicate that the as-prepared MCM-41/Napro/Fe2O3 composite has a potential application as a drug nanocarrier for magnetic-targeted drug delivery.

Highlights

Porous materials, their nature, and properties are often related to the inclusion phenomena
The inclusion chemistry of porous materials represents their extraordinary feature for which the porous materials are widely used in different applications, such as adsorption, separation, ion exchange, drug delivery, etc. [1,2,3]
In the light of the above-mentioned studies and advantages of magnetic mesoporous silica, in the present study, we focused on the investigation of drug delivery composite (DDC) system of mesoporous silica containing the iron oxide nanoparticles and naproxen drug

Summary

Introduction

Their nature, and properties are often related to the inclusion phenomena. The inclusion chemistry of porous materials represents their extraordinary feature for which the porous materials are widely used in different applications, such as adsorption, separation, ion exchange, drug delivery, etc. Mesoporous silica has been extensively studied in recent years due to its interesting properties and structural features. Large surface areas and pore volumes of mesoporous silicas, together with the narrow and controlled pore-size distribution and their rich intrapore chemistry, make these materials very attractive as supports for different applications [4,5,6,7]. Extraordinary properties of ordered mesoporous silica materials have stimulated research in areas that include fundamental studies on sorption and phase transitions in confined spaces, ion exchange, formation of various metal clusters, and loading different guest molecules, including biomolecules.

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Conclusion