Abstract
This article reports, for the first time, the ‘proof-of-concept’ results on magnetic monetite (CaHPO4)-based calcium phosphate cements (CPCs) compositions developed for the hyperthermia treatment of bone tumors. Hyperthermia involves the heating of a tumor within a temperature range of 40–45 °C, inducing apoptosis in the tumor cells. This process holds promising potential in the field of cancer treatment and has been proven to be more effective than conventional therapeutics. Hence, we aimed to develop cement compositions that are capable of the hyperthermia treatment of bone tumors. To achieve that central goal, we incorporated iron oxide (Fe3O4), a ferromagnetic material, into monetite and hypothesized that, upon the application of a magnetic field, magnetite will generate heat and ablate the tumor cells near the implantation site. The results confirmed that an optimized content of magnetite incorporation in monetite can generate heat in the range of 40–45 °C upon the application of a magnetic field. Furthermore, the compositions were bioactive and cytocompatible with an osteoblastic cell line.
Highlights
The major theme of this paper is to develop a monetite-based calcium phosphate cement (CPC) composition capable of generating heat in the range of 40–45 ◦ C to remove malignant bone tumors
Bone is a major site of metastasized cells, with 80% of them originating from malignant tumor cells of the breast and pancreas [1]
CPCs with initial setting times in the range of 3–8 min and final setting times of less than 15 min satisfy the requirement for cement application in clinical use [18]
Summary
CaHPO4 )-based calcium phosphate cement (CPC) composition capable of generating heat in the range of 40–45 ◦ C to remove malignant bone tumors. The ultimate product of this effort is a self-setting iron oxide (Fe3 O4 )-ceramic composite that is capable of generating sufficient heat to kill cancer cells, while preserving its bioactivity and biocompatibility with healthy bone cells. Bone is a major site of metastasized cells, with 80% of them originating from malignant tumor cells of the breast and pancreas [1]. The conventional treatment methods for treating such bone tumors are surgery, radiation therapy, and chemotherapy. Chemotherapy requires a strict diagnosis and prognosis and has significant side effects on Materials 2020, 13, 3501; doi:10.3390/ma13163501 www.mdpi.com/journal/materials
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
