Abstract
Among the number of hyperthermia materials, magnetic nanoparticles have received much attention. In this work, we studied the heating characteristics of uniform Fe@Fe3O4 core–shell nanoparticle under near-infrared laser irradiation and external AC magnetic field applying. The Fe@Fe3O4 core–shell nanoparticles were prepared by thermal decomposition of iron pentacarbonyl and followed by controlled oxidation. The prepared uniform particles were further coated with dimercaptosuccinic acid to make them well dispersed in water. Near-infrared derived photothermal study of solutions containing a different concentration of the core–shell nanoparticles was made by using 808 nm laser Source. Additionally, magnetic hyperthermia ability of the Fe@Fe3O4 nanoparticle at 150 kHz and various oersted (140–180 Oe) condition was systemically characterized. The Fe@Fe3O4 nanoparticles which exhibited effective photo and magnetic hyperthermia are expected to be used in biomedical application.
Highlights
Nanoparticles, such as silica, iron oxide, zinc oxide, and gold nanoparticles, have attracted much research interest for various biomedical applications, for instance, bioimaging [1,2,3,4], hyperthermia treatment [5,6,7,8] and other therapeutic applications [9,10,11,12]
Unlike gold nanoparticles which possess a mechanical weakness in photothermal process, most of the magnetic nanoparticles do not show obvious morphology changed during magnetic hyperthermia experiments
The results suggest that Fe@Fe3O4 core–shell nanoparticles have sufficient strength to withstand the stress from external magnetic fields
Summary
Nanoparticles, such as silica, iron oxide, zinc oxide, and gold nanoparticles, have attracted much research interest for various biomedical applications, for instance, bioimaging [1,2,3,4], hyperthermia treatment [5,6,7,8] and other therapeutic applications [9,10,11,12]. Gold nanoparticles are known as the most effective photothermal material due to the surface plasmon phenomenon which enhancing the photothermal effect. The mechanical weakness of gold nanoparticles limited their actual applications in the biomedical field. Many efforts have been made to prepare new photothermal materials with enhanced mechanical strength [13,14,15,16]. Unlike gold nanoparticles which possess a mechanical weakness in photothermal process, most of the magnetic nanoparticles do not show obvious morphology changed during magnetic hyperthermia experiments. Many kinds of research have been made to prepare magnetic nanoparticles with high magnetic saturation value [17, 18] for more effective heat generation [19,20,21]
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