Magnetic and heating aptitudes of PEG coated [formula omitted] and [formula omitted] mediators towards hyperthermia methodology

Abstract

In the present study functionalized mediator of Lanthanum strontium manganite (LSMO) has been investigated for magnetic fluid hyperthermia (MFH) applications. Perovskite structured (La1−xSrxMnO3) employing two Sr concentrations (x = 0.27 & 0.33) were attempted to coat with long chain structured polymer named Polyethylene glycol (PEG- 6000 g/mol) by adopting novel concentrations (5% & 14% w/v) in order to assess a detailed comparison of the effect of concentration of same coating material on two different LSMO's series. The Citrate-gel route was adopted to synthesize LSMOs nanoparticles (NPs). XRD revealed the super-paramagnetic (SPM) nature of synthesized NPs showing an approximate crystallite size of ∼17 nm. The LSMOs tailored with PEG showed an effective bonding of polymer with NPs exhibited by FTIR spectra. The magnetic parameters of coated NPs subjected to VSM at room temperature displayed an appreciable saturation magnetization and very slight coercivity owing to their SPM behaviour. During each synthesis, the relative proportions of polymer attached to LSMOs were evaluated through TGA analysis accompanied by DTA studies showing successive decomposition processes. The induction heating behaviours of NPs under an external radio frequency field displayed quite an appreciable approach for required Hyperthermia efficacy in the required range of 40–60 °C. Besides this, the coated NPs were dispersed in normal saline as an innovative try forming a ferro-fluid (∼19 mg/ml) and showed considerable approach towards induction heating for the destruction of cancerous cells employing hyperthermia methodology.