Magnesium-Molybate Compounds as Matrix for 99Mo/99mTc Generators

Fabiola Monroy-Guzman,Thania Susana Jimenez Martinez,Humberto Arriola,Luis Carlos Longoria Gandara

doi:10.3390/ph4020215

Fabiola Monroy-Guzman, Thania Susana Jimenez Martinez + Show 2 more

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https://doi.org/10.3390/ph4020215

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Abstract

This work reports the preparation of a 99mTc generator based on conversion of 99Mo produced by neutron irradiation, into insoluble magnesium 99Mo-molybdates compounds as matrix. The effect of magnesium salt types and concentration, Mg:Mo molar ratios, pH of molybdate solutions, eluate volume as well as the addition order of molybdate and magnesium solutions' influences on the final 99mTc were evaluated. Polymetalates and polymolybdates salts either crystallized or amorphous were obtained depending on the magnesium salt and Mg:Mo molar ratio used in matrix preparation. 99Mo/99mTc generator production based on magnesium-99Mo molybdate compounds allow reduction of preparation time and eliminates the use of specialized installations. The best generator performances were attained using matrices prepared from 0.1 mol/L MgCl2·6H2O solutions, ammonium molybdate solutions at pH 7 and at a Mg:Mo molar ratio of 1:1.

Highlights

Technetium-99m (99mTc) is used for more than two thirds of nuclear imaging techniques because of its short 6.02 h half-life, simple decay scheme, minimum whole-body dose, versatile chemistry, and availability from the 99Mo/99mTc generator [1,2]
Alternative methods of 99Mo/99mTc generator production have been investigated using low and medium specific activity 99Mo, produced from (n,γ) nuclear reaction with natural Mo and directly converted into insoluble substrates that can be eluted in a column. 99Mo/99mTc generator based on heteropolyanions such as zirconium molybdate, titanium molybdate, molybdocerates, etc., [6,7,8,9,10,11,12] have been developed by some laboratories around the world
In weight of 99Mo [13] compared to 0.2% in traditional alumina based generators. These generators has opened a way of making column type 99mTc generator even using low and medium specific activity 99Mo, the handling problems still exist because these 99Mo-molybdates are mostly synthesized from 99Mo, requiring sophisticated remote handling facilities and at least 6 h processing time [12,14]

Summary

Introduction

Technetium-99m (99mTc) is used for more than two thirds of nuclear imaging techniques because of its short 6.02 h half-life, simple decay scheme (a single 141 KeV photon), minimum whole-body dose, versatile chemistry, and availability from the 99Mo/99mTc generator [1,2] This system is based on Pharmaceuticals 2011, 4 adsorption of 99Mo on an alumina column where 99mTc formed from decay of the 99Mo is periodically eluted from the column using physiological saline, as sodium pertechnetate (Na99mTcO4) while. In weight of 99Mo [13] compared to 0.2% in traditional alumina based generators These generators has opened a way of making column type 99mTc generator even using low and medium specific activity 99Mo, the handling problems (precipitation, filtration drying, fragmentation, etc.) still exist because these 99Mo-molybdates are mostly synthesized from 99Mo, requiring sophisticated remote handling facilities and at least 6 h processing time [12,14]. This approach has three advantages: (1) it eliminates the use of specialized installations for molybdates synthesis; (2)

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