Abstract
In the current global epidemic for Non Alcoholic Fatty Liver Disease (NAFLD), diabetes and neuro-degenerative diseases such as Alzheimer’s disease there has been a major interest in magnesium therapy to delay the severity of NAFLD, Type 3 diabetes and neurodegeneration in the developing and developed world. The objective of magnesium therapy is to activate the anti-aging gene Sirtuin 1 (Sirt1) to prevent cardiovascular disease, NAFLD and diabetes. Reduced consumption of nutrients such as fatty acids, glucose, cholesterol and increased magnesium consumption is closely linked to reduced bacterial lipopolysaccharides (LPS) and activation of Sirt1 relevant to active nuclear and mitochondria interactions with the prevention of myocardial infarction and Type 3 diabetes. Magnesium deficiency and its effects on Sirt1 regulation have become important with magnesium deficiency associated with appetite dysregulation, senescence, glucose/nitric oxide dyshomeostasis, increased ceramide and toxic amyloid beta formation. Magnesium therapy activates the peripheral sink amyloid beta clearance pathway with the reversal of cell senescence associated with various chronic diseases such as cardiovascular disease, Type 3 diabetes and Alzheimer’s disease.
Highlights
Interests in chronic diseases have increased globally with the release of the World Health Organization (WHO, How to cite this paper: Martins, I.J. (2016) Magnesium Therapy Prevents Senescence with the Reversal of Diabetes and Alzheimer’s Disease
A low calorie diet is essential and recommended for the treatment of Non Alcoholic Fatty Liver Disease (NAFLD) and obesity and the benefit of this dietary regime is quite likely to lead to Sirtuin 1 (Sirt1) activation with improved peripheral cholesterol metabolism and reduced effects of LPS
Cell senescene with relevance to Sirt1 has become important to the prevention of various chronic diseases that include cardiovascular disease, NAFLD and Type 3 diabetes
Summary
Interests in chronic diseases have increased globally with the release of the World Health Organization (WHO, How to cite this paper: Martins, I.J. (2016) Magnesium Therapy Prevents Senescence with the Reversal of Diabetes and Alzheimer’s Disease. Reversal of cell senescence involves magnesium and Sirt1 interactions that improve appetite dysregulation connected to autonomous disease and Type 3 diabetes in a population by activation of other anti-aging genes that may delay the rate of chronic diseases [24] [25] (Figure 1).
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