Abstract
BackgroundLiterature data indicate the benefit of magnesium (Mg) supplementation. The aim of this study was to examine the effect of short-term Mg supplementation on iron status in healthy female participants.MethodsOne hundred healthy female students of the University of Belgrade - Faculty of Pharmacy participated the study during eleven intervention days. Students ingested Mg preparations with the same dose of the active substance. The analysis included the measurement of serum iron, unsaturated iron binding capacity (UIBC), total iron binding capacity (TIBC), total Mg (tMg), ionized Mg (iMg), complete blood count, met-, carboxyand oxy-haemoglobin (metHgb, COHgb, O2Hgb). Transferrin concentrations and percentage of transferrin saturation (SAT) were calculated manually. The association among the analyzed biochemical parameters was examined using polynomial regression. A principal component analysis (PCA) was used for the evaluation of interdependence between the analyzed parameters.ResultsA statistically significant trend for change in O2Hgb (%) by tertiles of iMg concentrations was found (P = 0.029). Serum tMg reached significant positive correlation with the SAT at concentration levels greater than 0.9 mmol/L, after 11 days of intervention (R2=0.116). Ionized Mg in a concentration higher than 0.6 mmol/L is positively correlated with SAT and serum Fe (R2=0.214; 0.199, respectively). PCA revealed variability of 64.7% for two axes after 11 days.ConclusionsMg supplementation leads to an improvement in the certain iron status parameters even in individuals with optimal levels of these indices. However, caution should be exercised when supplementing Mg, and laboratory monitoring of the interaction is required.
Highlights
Magnesium (Mg) plays an important role in many physiological functions
Given that the aim of this study was to examine the effect of the applied dose of magnesium of 375 mg, in which magnesium is most often found in dietary supplements on the Serbian market, data was further analysed without partition of subjects into sub cohorts in relation to different types of supplemented magnesium
The literature data indicate that the human body adapts to the additional intake of magnesium, calcium and phosphorus in the period from 7 to 10 days and that the mineral balance is achieved in the period of a few days after supplementation intake [29]
Summary
Magnesium (Mg) plays an important role in many physiological functions. Magnesium has an important role in macronutrient and energy metabolism, neuromuscular function, bone development, cell proliferation and signalling pathways [1, 2]. Magnesium is an essential micronutrient, and it must be supplied regularly via food sources to reach the recommended intake and prevent deficiency. Epidemiological studies have shown that people who follow a Western-style diet, characterized by a high intake of processed foods, have an inadequate intake of several micronutrients, with dietary Mg intake of less than 30–50% of RDA [11, 12]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
