Magnesium Sulfate Versus Lidocaine for Attenuating Hemodynamic Response to Tracheal Intubation

Abstract

Background: It is well recognized that the occurrence of hemodynamic responses in the form of rise in heart rate and blood pressure during and after laryngoscopy and endotracheal intubation mediated by sympathetic response, is a well- known treat. Objective: The aim of the study was to evaluate effects of magnesium sulfate and lidocaine in attenuating hemodynamic response at a certain doses based on previous studies. Patients and Methods: 76 patients were randomly divided into two groups (group M and group L) using computer generated randomization table, and induced by magnesium sulphate (30 mg・kg−1) or 2% lidocaine (2 mg・kg−1), infused in 3 minutes using syringe pump, after 3 minutes of pre-oxygenation, we proceeded for anesthetic induction by 2 mg/kg propofol and after loss of consciousness, 0.5 mg/kg atracurium (a muscle relaxant). All patients in both groups were intubated by the same anesthetist (the researcher) with direct laryngoscopy 3 minutes after administration of magnesium sulfate or lidocaine. Results: There was statistically non-significant difference between the studied groups regarding age, gender, weight, height, body mass index, ASA, presence of diabetes or hypertension, systolic or diastolic blood pressure values baseline, mean arterial blood pressure and heart rate values baseline at a time range of 1 to 5 minutes, while, there was statistically significant difference between the studied groups regarding the same measurements at a time range of 5 to 15 minutes. Conclusion: we conclude that magnesium sulphate is better alternative to lignocaine for attenuation of stress responses of laryngoscopy and intubation