Abstract
The effect of magnesium lauryl sulfate on tablet ejection force and filler compressibility was evaluated and compared to magnesium stearate in four direct compression fillers (micro- crystalline cellulose, compressible starch, spray-dried lactose, and direct compression sucrose) and a typical wet granulation (terra alba) using a rotary tablet press instrumented to monitor ejection and compression forces. Generally, higher concentrations of magnesium lauryl sulfate were required to produce ejection forces similar to those obtained with magnesium stearate. However, batches employing magnesium stearate were generally less compressible than batches employing magnesium lauryl sulfate at levels sufficient to produce similar or lower ejection forces.
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