Abstract
Hypothesis: Although mineral deficiency in particular magnesium is a known risk factor for cardiovascular disease intervention experiments with magnesium show only modest results. Previously published data suggest that there may be particular risk groups in the population. The study was undertaken to investigate if such risk groups could be identified. Experimental design: Subjects (n = 31) were 50 - 79 years old with no disease. The 24 hour urinary excretion of urea (proxy for acidity), magnesium, calcium, and potassium was measured at two week intervals, with and without intervention with mineral water. Intervention with mineral water comprised 75 mL daily, supplying 3.1 mmol Mg, 2.3 Ca, and 0.02 K. Major results: There was a significant relation between acidity and excretion of magnesium, calcium, and potassium, both at one occasion and regarding changes over time. Among subjects with a high secretion of urea there was an inverse relation between the excretion of magnesium and systolic blood pressure. After intervention with mineral water, there was a strong tendency to a decrease in the systolic blood pressure among those with an initial high excretion of urea and a low excretion of magnesium. Conclusions: The results demonstrate the importance of acid-base conditions for mineral homeostasis and suggest the presence of risk groups in the population, related either to a low intake or to a disorder in the reabsorbtion mechanisms. Mineral water decreased the systolic blood pressure in that particular risk group.
Highlights
Cardiovascular diseases are a large public health problem in Western countries and preventive actions have a high priority from a public health point of view
In a previous study a significant decrease in blood pressure was found after intervention with mineral water but only among subjects with an initial low urinary excretion of magnesium [9]
This risk group concept is supported by a study in the Netherlands, where a relation was found between stroke mortality and the magnesium content in drinking water but only among males with a dietary inadequate intake of magnesium [10]
Summary
Cardiovascular diseases are a large public health problem in Western countries and preventive actions have a high priority from a public health point of view. In a previous study a significant decrease in blood pressure was found after intervention with mineral water but only among subjects with an initial low urinary excretion of magnesium [9]. This suggests the presence of a risk group in the population with regard to magnesium homeostasis and blood pressure increase. 1) further explore the relation between the acid-base balance and urinary excretion of minerals in a randomly chosen population group; 2) explore the presence of particular groups at risk for high blood pressure; 3) assess the possibility to intervene in these groups with mineral rich water
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