Abstract
Several changes of magnesium (Mg) metabolism have been reported with aging, including diminished Mg intake, impaired intestinal Mg absorption and renal Mg wasting. Mild Mg deficits are generally asymptomatic and clinical signs are usually non-specific or absent. Asthenia, sleep disorders, hyperemotionality, and cognitive disorders are common in the elderly with mild Mg deficit, and may be often confused with age-related symptoms. Chronic Mg deficits increase the production of free radicals which have been implicated in the development of several chronic age-related disorders. Numerous human diseases have been associated with Mg deficits, including cardiovascular diseases, hypertension and stroke, cardio-metabolic syndrome and type 2 diabetes mellitus, airways constrictive syndromes and asthma, depression, stress-related conditions and psychiatric disorders, Alzheimer’s disease (AD) and other dementia syndromes, muscular diseases (muscle pain, chronic fatigue, and fibromyalgia), bone fragility, and cancer. Dietary Mg and/or Mg consumed in drinking water (generally more bioavailable than Mg contained in food) or in alternative Mg supplements should be taken into consideration in the correction of Mg deficits. Maintaining an optimal Mg balance all through life may help in the prevention of oxidative stress and chronic conditions associated with aging. This needs to be demonstrated by future studies.
Highlights
Mg and Requirement deposited in boneIts intestinal absorption, kidney excretion, the bone storage and the Mg constant and tightly preserved within this narrow range by a dynamic balance requirement different tissues
Several changes of magnesium (Mg) metabolism have been reported with aging, including diminished Mg intake, impaired intestinal Mg absorption and renal Mg wasting
Mg deficit may be involved in other mechanisms described in COVID-19, such as the immune hyperresponsiveness with excessive release of inflammatory mediators leading to the cytokine storm, endothelial dysfunction, thrombotic complications, and pre-existent predisposing conditions that worsen the prognosis of COVID-19 clinical course, such as old age, diabetes and hypertension
Summary
Its intestinal absorption, kidney excretion, the bone storage and the Mg constant and tightly preserved within this narrow range by a dynamic balance requirement different tissues. Are not a sufficiently precise measure ofnot the enough body Mg status; MgT levels are subclinical deficits on a single subject [8]. This serumaccurate total Mgtolevels not moreMg useful in epidemiological studies, but is arebecause not enough detectdosubclinical accurately mirror intracellular concentrations, and low intracellular. Mg deficits on a single subject [8] This is because serum total Mg levels do not accurately precede alterations of serum. Osmotic diuresis or drugs may cause hypomagnesemia, by
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