Magnesium Hydroxide as Curative Strategy against Lactic Acidosis in Goat

Abstract

Lactic acidosis is a metabolic disorder caused by feeding errors. It represents a significant economic loss due to direct as well as indirect effects. In present study a total of twenty four goats were focused in order to observe the efficacy of Magnesium hydroxide against induced lactic acidosis. Goats were divided into two groups viz., A and B. Goats in group A were induced lactic acidosis by offering over feeding of grains, while group B was kept as control and normal diet was provided to the goats. After appearance of clinical signs, goat in group A were treated with Magnesium hydroxide at the dose rate of 1g/Kg body weight on the interval of 24, 48 and 72 hours. Results indicated body temperature, ruminal pH, blood pH, respiration rate and heart rate attained normal level after the treatment with Magnesium hydroxide. Serum biochemical examinations of liver function after induction of lactic acidosis revealed that glucose level (190.14±36.49mg/dl), total bilirubin (0.75±0.04mg/dl), direct bilirubin (0.27±0.03mg/dl), indirect bilirubin (0.40±0.03mg/dl), alanine aminotransferase (36.42±3.04 U/L) and alkaline phosphatase (420±3.65 U/L) were significantly (P less than 0.05) increased. Magnesium Hydroxide helped in improving the normal physiological parameters but did not improved the rumen and intestinal motility. The hematological examination after the induction of lactic acidosis revealed hemo-concentration and increased Hb% (15.02±1.30) which significantly (P less than 0.05) became normal within 72hrs after Magnesium hydroxide therapy. Present study concludes that the Magnesium hydroxide is very helpful in minimizing the complications of lactic acidosis in goat, thus may be used as therapy of choice.