Abstract
BackgroundWe analyse magnesium levels in amniotic fluid to establish normal values for the 14th to 18th week of pregnancy and establish critical values that could be useful diagnostic and therapeutic guidelines for possible complications.FindingsNinety-two samples of amniotic fluid obtained by amniocentesis as well as the corresponding serum samples of pregnant women were analysed. The gestational age (mean ± SD) at which the amniotic fluid sample was obtained was 16.13 ± 1.87 weeks. Magnesium levels were determined by colorimetric assay with chlorophosphonazo-III using the the Cobas c 501 analyser (Roche Diagnostics). Statistical treatment of data was performed using the SPSS program, version 15.0.Results revealed a mean magnesium value of 1.65 ± 0.16 mg/dL in amniotic fluid and 1.97 ± 0.23 mg/dL in serum.ConclusionsIt would be interesting to extend the study to a larger number of pregnant women to determine variations in normal magnesium values in the three trimesters of pregnancy.
Highlights
We analyse magnesium levels in amniotic fluid to establish normal values for the 14th to 18th week of pregnancy and establish critical values that could be useful diagnostic and therapeutic guidelines for possible complications
It would be interesting to extend the study to a larger number of pregnant women to determine variations in normal magnesium values in the three trimesters of pregnancy
Amniotic fluid values for magnesium were slightly lower than serum values
Summary
We analyse magnesium levels in amniotic fluid to establish normal values for the 14th to 18th week of pregnancy and establish critical values that could be useful diagnostic and therapeutic guidelines for possible complications. 600 mL of amniotic fluid surrounds the baby at full term (40 weeks). This fluid is circulated constantly by the baby inhaling and swallowing existing fluid and replacing it through exhalation and urination [1]. Low levels of magnesium in amniotic fluid are associated with pregnancy complications such as preeclampsia [3] and diabetes [4,5]. Magnesium supplements have been demonstrated to reduce the frequency of delayed foetal growth, especially in low-birth-weight babies.
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