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Abstract
Magnesium (Mg) and fluoride (F) ions hold promising perspective for bone tissue regeneration by stimulating osteoblast cells proliferation and differentiation. Inspired by bone structure, Mg/F doped hydroxyapatite (HA) coatings with rapid surface apatite deposition ability and robust cytocompatibility will be an ideal bioactive coating for the surface functionalization of titanium implants. In this study, F doped HA (F-HA) coating, Mg doped HA (Mg-HA) coating and two superimposed double (Mg-F-HA) coatings were fabricated on titanium substrate by using pulsed laser deposition. In vitro bioactivity studies showed that three coatings exhibited different microstructure after soaking for 7 days: rice-like nano-porous structure (F-HA coating), 3D porous network structure (Mg-HA coating) and an ordered linear structure similar to cancellous bone (Mg-F-HA coating). For Mg-F-HA coating, it can better promote the transformation from apatite-like to HA phase due to the synergistic effect of Mg and F. Cell viability studies indicate that Mg/F doped HA coating can hold a good biocompatibility without cytotoxicity and improve the interfacial bioactivity of titanium substrate, specifically, both on regulation of biodegradation rate and good cellular proliferation. In summary, Mg/F doped HA structure yields a sustained bioactive coating for surface modification of titanium implant for rapid cell proliferation.
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