Abstract
Several drugs including diuretics and proton-pump inhibitors can cause magnesium loss and hypomagnesemia. Magnesium and drugs use the same transport and metabolism pathways in the body for their intestinal absorption, metabolism, and elimination. This means that when one or more drug is taken, there is always a potential risk of interaction with the magnesium status. Consequently the action of a drug may be adversely affected by magnesium (e.g., magnesium, calcium, and zinc can interfere with the gastrointestinal absorption of tetracycline antibiotics) and simultaneously the physiological function of minerals such as magnesium may be impaired by a drug (e.g., diuretics induce renal magnesium loss). Given the ever-increasing number of drugs on the market and the frequency with which they are used, greater attention must be paid in daily medical and pharmaceutical practice focused in particular on the adverse effects of drug therapy on magnesium status in order to minimize the potential risk to the health of patients.
Highlights
Thanks to modern health care and the improvement of life quality, the average life expectancy of Europeans has almost doubled over the past 100 years
The action of a drug may be adversely affected by magnesium and simultaneously the physiological function of minerals such as magnesium may be impaired by a drug
This study shows that the patients had normal serum magnesium, thiazide diuretics (TD) can induce intracellular magnesium depletion not detectable by assessment of blood serum [76]
Summary
Thanks to modern health care and the improvement of life quality, the average life expectancy of Europeans has almost doubled over the past 100 years. Gastric acid secretion approaches the lower limit of adult values by 3 months of age Both gastric emptying time and small intestine peristalsis tend to be slow the later part of the first year of life. Aminoglycosides are administered every 8 hours in older children, every 12 hours in newborns, and every 24 hours in premature infants Drugs such as phenobarbital, which have a sedating action on adults, may produce hyperactivity in children [16,17,18]. These changes in the acid-base balance are small, it has been shown that a diet-induced slight decrease in blood pH can have a significant impact on metabolism (e.g., bone) and mineral excretion [25,26]. The ingestion of alcohol and caffeine increase the renal excretion of magnesium causing an increase in the body’s demand) [25,26,27,28]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
