Abstract
Magnesium alloy covered stents have rarely been used in the common carotid artery (CCA). We evaluated the long-term efficacy of magnesium alloy covered stents in a lateral aneurysm model in rabbit CCA. Magnesium alloy covered stents (group A, n = 7) or Willis covered stents (group B, n = 5) were inserted in 12 New Zealand White rabbits and they were followed up for 12 months. The long-term feasibility for aneurysm occlusion was studied through angiograms; the changes in vessel area and lumen area were assessed with IVUS. Complete aneurysmal occlusion was achieved in all aneurysms. Angiography showed that the diameter of the stented CCA in group A at 6 and 12 months was significantly greater than the diameter immediately after stent placement. On intravascular ultrasound (IVUS) examination, the mean lumen area of the stented CCA in group A was significantly greater at 6 and 12 months than that immediately after stent placement; the mean lumen area was also significantly greater in group A than in group B at the same time points. The magnesium alloy covered stents proved to be an effective approach for occlusion of lateral aneurysm in the rabbit CCA; it provides distinct advantages that are comparable to that obtained with the Willis covered stent.
Highlights
Stenosis (>3 0%) of the stented common carotid artery was observed in one rabbit with a magnesium alloy covered stent immediately after stent placement; this resolved 3 months after stent placement
This study was designed to compare the in vivo efficacy of the two covered stents for treatment of lateral aneurysm in rabbit CCA
The main findings of the study are the following: (1) the magnesium alloy covered stent, with magnesium alloy stent degradation over time, is an effective approach for occlusion of the lateral aneurysm model in rabbit CCA; (2) in group A, in which the magnesium alloy covered stents were used, the mean diameters of the stented CCAs at 6 and 12 months were significantly greater than that at stent placement, the mean diameter of the stented CCAs in group A was significantly greater than the mean diameter in group B at 6 or 12 months follow-ups
Summary
The purpose of this study was to evaluate the long-term efficacy of the magnesium alloy covered stents for treatment of lateral aneurysm in the rabbit CCA, its in vivo degradation behavior, and the intravascular ultrasound grayscale results
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