Abstract
The interfacing of separation methods with selective detectors has been a long sought after goal. In some instances, such as gas chromatography interfaced with spectrometric methods such as mass spectrometry or Fourier transform infrared spectrometry, considerable success has been achieved. Interfaces with liquid chromatography have been far less successful due to the difficulty in eliminating the mobile phase. In the infrared, liquid mobile phases must be eliminated as they are opaque at all wavelengths at even short path lengths. The solutes are generally in such low concentration that long path lengths must be used to record their spectra in the presence of the solvent. Nonetheless, the solvent opacity precludes this option. Solvent elimination has been possible for high volatility nonpolar mobile phases, yet the majority of liquid chromatography is accomplished with polar (reverse phase) solvents. An interface has been developed that can accommodate both normal and reverse phase solvent systems, as well as gradient elution systems. This interface is the monodisperse aerosol generation interface for combining liquid chromatography with Fourier transform infrared spectrometry.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
