Abstract
Case reportWe present the clinical cases of two male patients aged 38 and 39 years, diagnosed with Alport's syndrome (AS), who suffered a bilateral macular hole (MH) and a giant unilateral MH with retinal thinning in the other eye, respectively. DiscussionAS is a genetic disorder characterized by mutation of genes encoding type IV collagen, the main component of the internal limiting membrane (ILM), a structure identified in basal membrane of the retinal pigment epithelium–Brüch's membrane complex. This alteration can influence the predisposition to MHs.
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