Abstract
A macroscopic model describing the influence of nitrogen on a fed-batch baker's yeast production process is proposed. First, on the basis of a set of biological reactions, inspired by the model of Sonnleitner and Käppeli (1986), a model in which the nitrogen and glucose consumption are coordinated is proposed. Second, an attempt of estimating trehalose concentration in yeast cells through an extension of this model is presented. The model parameters are obtained via a non-linear least squares identification. It is validated with experimental data and successfully predicts the dynamics of growth, substrate consumption (nitrogen and carbon sources) and metabolite production (ethanol and trehalose). This model allows, on the one hand, quantitatively describing the link between nitrogen and glucose consumption in yeast cultures and, on the other hand, will be valuable for the determination of culture conditions aiming at maximizing yeast productivity while guaranteeing the accumulation of a required amount of trehalose.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
