Macroporous bacterial cellulose grafted by oligopeptides induces biomimetic mineralization via interfacial wettability

Abstract

Bacterial cellulose (BC) has a role in tissue repair and regenerative medicine, which has already attracted tremendous interest from researchers, especially those working in the field of hybrid materials. Herein, we designed BC-based macroporous functional materials by dialdehyde bacterial cellulose (DBC) cross-linking with oligopeptides under mild reactive conditions. The interfacial properties of the surface modified BC were examined by biomimetic mineralization. The results showed that a macroporous structure was achieved by using oligopeptides as chemical cross-linking agents with an interconnected macroporosity ranging from 20 μm to 80 μm. Their mechanical properties were barely altered compared to the pristine BC. Their enhanced surface charges stemmed from the carboxyl groups of the oligopeptides engaging in reactions with amine and aldehyde groups. The oligopeptides cross-linked DBC showed a faster initial induction towards minerals via interfacial wettability resulting in promotion of mineralization, the hybrid materials had excellent biocompatibility relative to the pristine BC. These findings are vital to the development of other biopolymers with essential macroporous structures as well as improved interfacial wettability, which enables their possible uses in tissue repair and regenerative medicine.