Abstract
Part I Macrophage: Origin, Activation And Polarization.- Blood monocytes and their subsets in health and disease.- Polarized activation of macrophages.- Alternative activation of macrophages: concepts and prospects.- Regulatory macrophages and the maintenance of homeostasis.- Part II Macrophages And Their Diverse Functions.- Phagocytosis.- The antimicrobial functions of macrophages.- Vascular modulatory functions of macrophages.- Part III Macrophages In Different Tissues.- Airway macrophages: sentinels of health.- Microglial ontogeny and functions in shaping brain circuits.- Kupffer cells in health and disease.- Intestinal Macrophages: Specialized antigen-presenting cells at the front line.- Part IV Macrophages In Pathology.- The wound macrophage - Macrophages and the entrance of resolution phase lipid mediators.- Macrophages in sepsis progression.- Adaptive characteristics of innate immune responses in macrophages.- African trypanosomiasis as paradigm for involvement of the mononuclear phagocyte system in pathogenicity during parasite infection.- Macrophages in obesity and insulin resistance.- Macrophages govern the progression and termination of inflammation in atherosclerosis and metabolic diseases.- Myelomonocytic subsets in tumor microenvironment.- Tumor associated macrophages.- Part V Transcriptional And Epigenetic Mechanisms.- Role of NF-kB activation in macrophages.- Interferon Regulatory Factors: Role in transcriptional regulation of macrophage plasticity and activation.- Kruppel-like factors in Monocyte-Macrophage Biology.- Regulation of macrophage polarization by the STAT-SOCS signaling axis.- Functions of the large Maf transcription factors and macrophages.- The Control of Gene Expression in Macrophages.- Role of microRNA in macrophage activation and polarization.- Part VI Systems Biology Of Macrophages.- The macrophage transcriptome.- Omics approaches in macrophage biology.- Appendix.
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