Macrophages as Cytotoxic Effector Cells

Abstract

Cells of the mononuclear phagocyte system can be activated by lymphokines to both increased extracellular cytotoxicity against tumor targets and intracellular cytotoxicity against micro-organisms. In addition, these effector cells can kill antibody-coated target cells in an ADCC system. These two cytotoxic mechanisms can co-operate and act synergistically. Such an synergistic action is characterized by the specificity of the antibody which coates the target cells and not by the non-specific activation induced by high dosages of lymphokine. The lymphokine MCF has partially been purified and separated from a variety of other lymphokines. This purified material, when injected into mice intraperitoneally, activates the macrophages to strong cytotoxicity. Evidence obtained by the use of different rat anti-mouse macrophage monoclonal antibodies suggests that there exist different subpopulations of macrophage and that some of these subpopulations can be correlated to defined functions.