Abstract
AbstractBulk metallic glasses (BMGs) are considered to be a competitive candidate of biomedical materials, owing to their appealing mechanical properties and high thermal processability. Based on the established biosafety of the Zr‐based BMGs, macrophage responses to (Zr55Al10Ni5Cu30)99Y1 (atomic percent) BMG were investigated in the present study, in comparison with Ti‐6Al‐4V alloy. The adhesion of RAW 264.7 macrophages to both alloys was found to be mediated by protein adsorption. The Zr‐based BMG is capable of supporting regular adhesion and proliferation of macrophages, indicating its good biocompatibility, which agrees with previous findings using other mammalian cells. A lower degree of morphological activation was revealed on Zr‐based BMG substrates than on Ti‐6Al‐4V substrates, which is evidenced by smaller spreading areas and less ruffling on cell surfaces. Smaller amount of proinflammatory cytokine, tumor necrosis factor‐alpha, was secreted by macrophages cultured on Zr‐based BMGs, which further confirms the lower level of inflammation induced by BMG than by Ti alloys. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 3369–3378, 2014.
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