Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease that attacks almost every organ. The condition mostly happens to adults but is also found in children, and the latter have the most severe manifestations. Among adults, females, especially non-Caucasian, are mostly affected. Even if the etiology of SLE remains unclear, studies show a close relation between this disease and both genetics and environment. Despite the large number of published articles about SLE, we still do not have a clear picture of its pathogenesis, and no specific drug has been found to treat this condition effectively. The implication of macrophages in SLE development is gaining ground, and studying it could answer these gaps. Indeed, both in vivo and in vitro studies increasingly report a strong link between this disease and macrophages. Hence, this review aims to explore the role of macrophages polarization and plasticity in SLE development. Understanding this role is of paramount importance because in-depth knowledge of the connection between macrophages and this systemic disease could clarify its pathogenesis and provide a foundation for macrophage-centered therapeutic approaches.
Highlights
Systemic lupus erythematosus belongs to a group of autoimmune diseases commonly called lupus
Given the crucial role macrophages play in the development of Systemic lupus erythematosus (SLE), studies on this autoimmune disease are increasingly focusing on its relationship with these immune cells
Further research is needed to clarify this point. These findings address the association of macrophages with SLE and point out the implication of M1-like macrophages in the pathogenesis of the disease
Summary
Systemic lupus erythematosus belongs to a group of autoimmune diseases commonly called lupus. Later, when other systemic manifestations were reported, the name Systemic lupus erythematosus (SLE) was introduced [2]. Macrophages in Systemic Lupus Erythematosus role in the pathogenesis of SLE. A significant influence on the disease process is exerted by macrophage plasticity. This unique property of macrophages could enable the pursuit of these immune cells for therapeutic goals by inducing a phenotype switch between M1-/M2-like macrophages [9]. Given the crucial role macrophages play in the development of SLE, studies on this autoimmune disease are increasingly focusing on its relationship with these immune cells. The purpose of this review is to provide an up-to-date summary of the connection between Systemic lupus erythematosus and macrophages
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